Depressed Jane

Let Me Tell You More About My Depressed, Miserable Existence

Archive for May, 2006

Cyberonics, Inc. (Nasdaq: CYBX) today announced that the first nine patients have been enrolled in a year-long Vagus Nerve Stimulation (VNS) Therapy dosing study that will examine treatment outcomes for patients with treatment-resistant depression (TRD) who are randomized to three different doses of VNS Therapy.Approximately 460 patients at 30 study sites will be enrolled in themulti-center, double-blind, randomized study. [click link for full article]

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People suffering from depression will be able to have better accessto counselling and talking therapies under a major new programmeannounced today by UK Health Secretary Patricia Hewitt. At the moment many people with mild to moderate depression find itdifficult to access talking therapies, with services patchily spreadacross the country. [click link for full article]

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Calcium is a common intracellular signaling molecule with a wide range of functions in the brain, and the regulation as well as dysregulation of calcium signaling via the principal intracellular calcium release channel, InsP3R1, has been linked to many normal cellular processes as well as neurological diseases. In addition, the calcium binding protein, neuronal calcium sensor-1 (NCS-1), has been shown to regulate calcium signaling and NCS-1 expression is increased in bipolar patients. [click link for full article]

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Calcium is a common intracellular signaling molecule with a wide range of functions in the brain, and the regulation as well as dysregulation of calcium signaling via the principal intracellular calcium release channel, InsP3R1, has been linked to many normal cellular processes as well as neurological diseases. In addition, the calcium binding protein, neuronal calcium sensor-1 (NCS-1), has been shown to regulate calcium signaling and NCS-1 expression is increased in bipolar patients. [click link for full article]

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“A deeper understanding of the biology of suicidal behavior may facilitate the development of new pharmacological interventions that could be targeted at vulnerable individuals, potentially saving thousands of lives,” say Jonathan Savitz and colleagues from the University of Cape Town. Identifying the genes that contribute to the risk for suicidal behavior is an integral part of this process, say the authors. [click link for full article]

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“A deeper understanding of the biology of suicidal behavior may facilitate the development of new pharmacological interventions that could be targeted at vulnerable individuals, potentially saving thousands of lives,” say Jonathan Savitz and colleagues from the University of Cape Town. Identifying the genes that contribute to the risk for suicidal behavior is an integral part of this process, say the authors. [click link for full article]

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GlaxoSmithkline, the makers of the antidepressant, Paxil, have warned that the drug may raise the risk of suicide attempts in people under 30. Glaxo has sent a letter to doctors stating this. According to a clinical trial, of 3,455 people taking Paxil 11 tried to kill themselves. Among the placebo group of 1,978 people, 1 tried to commit suicide. The majority of suicide attempts were made by patients under 30. One of the Paxil patients who attempted suicide succeeded. [click link for full article]

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People age 70 and older who continued taking the antidepressant that helped them to initially recover from their first episode of depression were 60 percent less likely to experience a new episode of depression over a two-year study period than those who stopped taking the medication, according to a study funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. [click link for full article]

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Whether depressed patients will respond to an antidepressant depends, in part, on which version of a gene they inherit, a study led by scientists at the National Institutes of Health (NIH) has discovered. Having two copies of one version of a gene that codes for a component of the brain’s mood-regulating system increased the odds of a favorable response to an antidepressant by up to 18 percent, compared to having two copies of the other, more common version. [click link for full article]

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If your treatment for depression has not worked during the first six to eight weeks your chances of recovery are greatly enhanced if you either add another medication or switch drugs completely, according to a new study. Just one third of patients who are treated for depression recover within twelve weeks. [click link for full article]

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