Depressed Jane

Let Me Tell You More About My Depressed, Miserable Existence

Archive for January, 2008

Depression affects huge numbers of people. One in four of us suffer from it at some point in our lives; one in ten will in the next year, and about one in twenty of us is living with the condition right now. Dr Paul Keedwell argues that, although depression is unpleasant and sometimes unbearable, it can have some long term benefits both for individuals and possibly for us as a species.

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Diabetes Blues, UK

By Depressed Jane on January 25, 2008

Diabetes UK is calling for more psychological support for young adults with Type 1 diabetes as new research shows that a third report symptoms of depression. We want diabetes services to be better targeted to meet the needs of young people. These improvements are urgently needed, as the study found that 35 per cent of young people taking part showed symptoms of depression.

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Matters of the mind can affect matters of the heart. A new study by Université de Montréal and McGill University researchers has found that major anxiety and/or depression, can double a coronary artery disease patient’s chances of repeated heart ailments. This is one of the first studies to focus on patients with stable coronary artery disease – not those who were hospitalized for events such as a heart attack.

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A new US study led by a researcher who used to review drug studies at the US Food and Drug Administration (FDA) suggests that selective reporting of the results of antidepressant drug trials in journals exaggerates their effectiveness. This could mislead doctors and patients into thinking antidepressants are more effective than they really are said the researchers.

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When withdrawal symptoms ensue after discontinuation of a drug, such as paroxetine, it is generally assumed they will last for a few weeks and then they will subside. Many patients do not think so and some of them have also created a website concerned with paroxetine discontinuation effects. Now researchers at the University of Bologna headed by Prof. G.A.

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Apparently not very much, according to a study by Dutch investigators published in the Jan 2008 issue of Psychotherapy and Psychosomatics.Maintenance antidepressant (AD) medication is the most commonly used preventive strategy in a highly recurrent disease, i.e. depression. Little is known about the discontinuation of maintenance AD use and the association with recurrence in daily clinical practice.

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CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases of the central nervous system, announced the successful completion of the Phase l clinical program for Tyrima(TM), its lead candidate for the treatment of depression and anxiety. Tyrima is a selective and reversible member of a novel class of drugs known as RIMAs, or reversible inhibitors of monoamine oxidase A.

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Women and men doctors have some divergent views about women and depression, according to a recent survey conducted by the Society for Women’s Health Research, a Washington, D.C., based advocacy organization. Women doctors are more likely than their male counterparts to believe that women are specifically susceptible to depression during two key times of hormonal transition in a woman’s life: puberty (67.5 percent to 48.2 percent) and perimonpause (92.8 percent to 67.

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Depression is one of the most common forms of psychopathology. According to diathesis-stress theories of depression, genetic liability interacts with negative life experiences to cause depression. Traditionally, most studies testing these theories have focused on only one component of the diathesis-stress model: either genetics or environment, but not their interaction.

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Gabriel Sciences, a Maryland biotech company founded by David Pickar MD, enters into a collaborative project, “Triple Re-Uptake Inhibitors: Potential Antidepressants.” Candidate compounds synthesized by the research team of Professor Paul Carlier PhD at Virginia Tech, and tested by the research team of Professor Elliott Richelson MD at Mayo Clinic, show activity in preclinical tests that are predictive of antidepressant activity in humans.

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