Depressed Jane

DOV Pharmaceutical, Inc. (OTCBB: DOVP) announced that it has initiated a Phase II clinical trial of DOV 21,947 in patients diagnosed with major depressive disorder. DOV 21,947 is DOV’s lead triple reuptake inhibitor, or “TRIP,” for the treatment of depression and obesity. The clinical trial, which will randomize approximately 200 patients, is a double-blind, placebo-controlled, multi-center study assessing the efficacy and safety of DOV 21,947 over a six-week period.

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In the last few days there has been widespread media coverage questioning the effect of antidepressant drugs, following the results of a study published in the journal Public Library of Science Medicine.The study suggested that some antidepressant drugs performed no better than dummy or placebo pills used in trials dating back to the 1980s.

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12 sessions of cognitive behavioural therapy (CBT) can be of significant help to people who self-harm, a new study from the Netherlands has found.

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More than half of teenagers with the most debilitating forms of depression that do not respond to treatment with selective serotonin reuptake inhibitors (SSRIs) show improvement after switching to a different medication combined with cognitive behavioral therapy, researchers at UT Southwestern Medical Center and their colleagues in a multicenter study have found.Dr.

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A new study by researchers in the UK suggests that antidepressants only benefit the very severely depressed and are no more effective than a placebo for everyone else.The meta-analytical study (ie one that systematically pools the results of other studies) is the work of Dr Irving Kirsch, from the University of Hull, and his colleagues, and is published today, 26th February, in the open access journal PLoS Medicine.

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The Royal College of Psychiatrists has urged people taking antidepressants not to discontinue their medication without consulting a doctor.NICE guidelines point to the efficacy of antidepressants as well as cognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) for people with moderate to severe depression. Many studies have shown that a combination of medication and psychotherapy has been particularly effective.

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Who benefits from antidepressants?A new study published today in PLoS Medicine suggests that antidepressants only benefit some, very severely depressed patients.”New generation” antidepressants, such as fluoxetine (Prozac) are widely prescribed for the treatment of clinical depression. However some studies have suggested that these drugs do not help the majority of depressed people get better by very much.

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For this year’s Sport Relief, the BBC and Comic Relief bring viewers Surviving Suicide, a sensitive and moving documentary for BBC One which explores the issues affecting those whose lives have been touched by suicide. Every year nearly 6,000 people in the UK take their own lives. The film features stories from everyday people; people who have attempted suicide and people who have been bereaved. Importantly the film shows how people can embark on a journey of recovery.

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Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly. Ketamine, a drug used in general medicine as an anesthetic, has recently been shown to produce improvements in depressed patients within hours of administration.

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There are numerous antidepressant medications currently on the market, but sadly, many patients still experience the debilitating symptoms of depression even with treatment.

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