Depressed Jane

Let Me Tell You More About My Depressed, Miserable Existence

Archive for March, 2008

A report in the March issue of Psychotherapy and Psychosomatics introduces a new hypothesis on the mechanisms of physical symptoms in depression: energy production rates toward the lower end of the spectrum may predispose the individuals to develop depression and physical symptoms.This hypothesis derives from a study performed in the Karolinska Institute.

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When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action? This is the question asked by researchers in a new report scheduled for publication in Biological Psychiatry on April 1st.

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In Love and Death, Woody Allen wrote: “To love is to suffer…To be happy is to love. To be happy, then, is to suffer.” The paradoxical merging of happiness and suffering can be a feature of depression. Biological Psychiatry, on April 1st, is publishing a new study of regional brain activity using functional magnetic resonance imaging, which may help further our understanding of how happiness and suffering are related in depression.

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While analyzing data from Saskatchewan health databases, Lauren Brown, researcher with the U of A’s School of Public Health, found people with a history of depression had a 30 per cent increased risk of type 2 Diabetes.Brown then studied the medical history of 2,400 people who were diagnosed with depression and were taking antidepressants to determine whether there was a clear correlation between that disease and type 2 Diabetes.

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Before swatting at one of those pesky flies that come out as the days lengthen and the temperature rises, one should probably think twice. A University of Missouri researcher has found, through the study of Drosophila (a type of fruit fly), that by manipulating levels of certain compounds associated with the “circuitry” of the brain, key genes related to memory can be isolated and tested.

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Corcept Therapeutics (NASDAQ: CORT) announced the commencement of its fourth Phase 3 trial, Study 14, evaluating CORLUX for the treatment of the psychotic features of psychotic depression. This trial is a randomized, double-blinded, placebo-controlled study which will enroll up to 450 patients at approximately 25 sites in the United States. In connection with this study Corcept also announced the signing of an agreement with MedAvante, Inc.

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Two articles in the March issue of the European Journal Psychotherapy and Psychosomatics raise serious concern about the increasing use of antidepressant medications. In the first article, David Healy and collaborators (University of Cardiff) formulate a critique of many studies which try to support the use of antidepressants on the basis of variations in suicide rates.

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A new study in the journal Family Process reveals that caregivers with moderate to severe depressive symptoms showed greater hostility and less warmth. The study focused on caregivers of low-income children with persistent asthma.

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As the second leading cause of death in college students after car accidents, suicide is a serious problem that can affect teenagers and young adults at an age when serious mental illness first manifests itself and often goes undiagnosed. A psychiatrist and an authority on suicide at Columbia University Medical Center and NewYork-Presbyterian Hospital offers parents and students advice on how to spot and address potentially suicidal behavior.

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Depression is not always manifested in children as dejection and anhedonia. Depending on the age of the child, the dominant features may be weeping, irritability or defiance, as explained by Prof. Claudia Mehler-Wex and Dr. Michael Kolch of Ulm University in the new edition of Deutsches Arzteblatt International (Dtsch Arztebl Int 2008; 105(9): 149-55).The signs of depression in infants are often screaming, restlessness, and weeping attacks for no clear reason.

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