Depressed Jane

Let Me Tell You More About My Depressed, Miserable Existence

Archive for March, 2008

Clinical Data, Inc. (NASDAQ:CLDA), a leader in the development of targeted therapeutics and predictive tests from its growing portfolio of proprietary genetic biomarkers, announced that it has initiated the second of its two pivotal trials of Vilazodone, the Company’s novel drug candidate for the treatment of depression. This double-blind, placebo-controlled clinical trial is designed to assess the efficacy and safety of Vilazodone.

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The signs of depression in infants are often screaming, restlessness, and weeping attacks for no clear reason. Preschool children may behave irritably and aggressively, while schoolchildren may be listless and apathetic. The symptoms in adolescents become similar to those in adults.It is thought that up to 3.5% of children and 9% of adolescents in industrial countries are depressive. In particular, the risk of depression increases from the age of 12.

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Individual genes do not cause depression, but they are thought to increase the probability of an individual having a depression in the face of other accumulating risk factors, such as other genes and environmental stressors. One gene that has been shown to increase the risk for depression in the context of multiple stressful life events is the gene for the serotonin transporter protein.

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Researchers from the University of Illinois at Chicago College of Medicine have discovered that a change in the location of a protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression and to determine whether a particular antidepressant therapy will provide a successful response.The research is published in the March 12 issue of the Journal of Neuroscience.

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A new discovery could change future diagnosis and therapy of depression.Researchers from the University of Illinois at Chicago College of Medicine have discovered that a change in the location of a protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression and to determine whether a particular antidepressant therapy will provide a successful response.

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Mental health charity Mind responds to the MHRA’s ruling on GlaxoSmithKline.Paul Farmer, chief executive of Mind, said:”Mind welcomes news that the Government is to increase drug companies’ responsibility to pass on clinical trials information. We look forward to discussions with ministers to ensure that patients’ interests are best served. We hope that the legislation will pass quickly through Parliament; this is far too important to be delayed any longer.

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The MHRA has concluded its four year investigation into Glaxosmithkline and its antidepressant drug Seroxat. The investigation focused on whether GSK had failed to inform the MHRA of information it had on the safety of Seroxat in under 18’s in a timely manner. The investigation was undertaken with a view to a potential criminal prosecution for breach of drug safety legislation.

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About 15% to 20% of U.S. soldiers in Iraq have signs of depression or post-traumatic stress disorder, and about 30% of soldiers on their third or fourth tours have experienced emotional illnesses, according to a study released on Thursday by the Army, USA Today reports (Zoroya, USA Today, 3/7).

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GlaxoSmithKline (GSK) notes the conclusions announced by the Medicines and Healthcare products Regulatory Agency (MHRA) regarding its investigation into disclosure of paediatric trial data for the anti-depressant medicine Seroxat (paroxetine).”The safe use of our medicines is paramount to everyone who works for GSK and the company is committed to ensuring that all appropriate information is made available to regulators, doctors and patients.

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In a recent article published in Archives of Pediatrics& Adolescent Medicine, another pregnancy is likely -within two years of having one child – for African American adolescentmothers with symptoms of depression.Author Beth Barnet, M.D (University of Maryland School of Medicine,Baltimore) and colleagues build on previous research that has shown agreater likelihood for teen mothers to experience depression comparedto adult mothers.

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