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Untreated Depressed People Have Fewer Serotonin & Opioid Receptors, And Variation Is Linked To Symptoms And Treatment Response

Depressed people may have far fewer of the receptors for some of the brain’s “feel good” stress-response chemicals than non-depressed people, new University of Michigan Depression Center research shows.And even among depressed people, the numbers of these receptors can vary greatly. What’s more, the number of receptors a depressed person has appears to be linked with the severity of their symptoms – and the chances that they’ll feel better after taking a medication.

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